40 papers
HIV/AIDS research remains a critical frontier in global health, focusing on everything from understanding how the virus interacts with the human immune system to developing new treatments and vaccines. This field is constantly evolving, with scientists working tirelessly to improve patient outcomes and move closer to a functional cure. Because these discoveries happen rapidly, staying updated with the latest findings is essential for both experts and the public.
At Gist.Science, we bridge the gap between complex research and clear understanding by processing every new preprint in this category directly from medRxiv. We transform these dense scientific documents into both plain-language explanations and detailed technical summaries, ensuring that the latest insights into HIV and AIDS are accessible to everyone. Below are the most recent papers we have analyzed, offering a fresh look at the ongoing fight against the virus.
In a two-year Kenyan study of people who inject drugs on dolutegravir-based antiretroviral therapy, approximately one-third experienced viral non-suppression, with living in improvised shelters identified as a significant risk factor, while dolutegravir resistance mutations remained rare despite frequent NNRTI resistance.
This retrospective cohort study at Lira Regional Referral Hospital found that while early infant diagnosis uptake among HIV-exposed infants was sub-optimal compared to national targets, timely administration of cotrimoxazole was significantly associated with the timely completion of the diagnosis process.
This retrospective cohort study of 37,642 patients in Njombe, Tanzania, reveals that 35.6% were lost to follow-up between 2017 and 2021, with significant predictors including poor pharmacy refill adherence, being single or divorced, and residing in the Wangingombe district, while the 2021 cohort showed improved retention.
This global systematic review and meta-analysis of 91 studies involving nearly 180,000 female sex workers across 37 countries demonstrates that experiencing violence is significantly associated with higher odds of prevalent HIV infection and reduced odds of ART use and viral suppression, highlighting violence as a critical structural determinant that must be addressed in HIV interventions.
This retrospective cohort study in Tanzania's Manyara region demonstrates that pharmacy refill adherence is a strong predictor of loss to follow-up among people living with HIV, revealing significant geographic disparities linked to nomadic lifestyles and highlighting the critical need for unique patient identifiers and mobility-friendly retention strategies to improve care continuity.
This study models the impact of abrupt USAID and CDC funding cuts in KwaZulu Natal, South Africa, revealing that such cessation would significantly increase HIV incidence and mortality by 2030, while restoring funds within 12 months and reallocating them to long-acting PrEP could substantially avert new infections and help realign the province with epidemic control goals.
This cross-sectional study conducted in Kampala, Uganda, reveals that approximately 3.2% of patients on antiretroviral therapy with undetectable viral loads yield false-negative results on rapid HIV diagnostic tests, a phenomenon significantly associated with higher CD4 counts and longer duration on treatment, suggesting that serial rapid testing alone may be insufficient for this population.
This mixed-methods study in India demonstrates that while a peer-led running intervention improves mental health for adolescents with perinatally acquired HIV, its effectiveness is significantly hindered for girls by gendered social barriers, highlighting the urgent need for gender-transformative program designs to ensure equitable outcomes.
This target trial emulation study utilizing routine data from Malawi's HIV program demonstrates that six-month antiretroviral therapy dispensing (6MMD) is associated with slightly but significantly higher retention rates at 12 and 24 months compared to shorter dispensing intervals.
This study analyzes 2016/17 and 2022/23 national survey data to reveal that while HIV testing uptake among young women in mainland Tanzania increased from 86% to 90%, it stagnated at 40% for adolescents, with consistent determinants including union status, higher education, and STI history, underscoring the need for age-specific intervention strategies.